Department of Chemistry, SUNY Potsdam

DoD Program Idea Grant previous next  

Redox Abnormalities as a Vulnerability Phenotype for Autism and Related Alterations in CNS Development

PI: Professor Maria Hepel

Major Accomplishments                                                                       

8. Microsensor arrays for determination of biomarkers of oxidative stress

Maria Hepel and Magdalena Stobiecka, "Microsensor Arrays for Determination of Biomarkers of Oxidative Stress", in: Bioelectronics, Biointerfaces, and Biomedical Applications 4,, M. Madou, A. Hoff, D. Landheer, L. Nagahara, K. Sode, T. Thundat, C. Wang [Eds.], ECS Transaction, 35/u> [7] (2011) 125-134.


      Microsensors for the detection of biomarkers of oxidative stress have been investigated in view of the need for a wide scale testing of children for the development of autism which is partly associated with inadequate defenses against reactive oxidant species and radicals. Several sensor types for glutathione, which is the main peptide participating in the redox-potential homeostasis in eukaryotic cells, have been designed including anti-glutathione monoclonal antibody based sensor, molecularly-templated poly(orthophenylenediamine) sensors, and transition metal complex electrocatalyst based sensors. The microsensor arrays accommodating glutathione sensors with different responses to the matrix background and interferences have been constructed. For the analysis of sensor array outputs, specially designed artificial neural networks have been employed.




Sensor array design